Table 2.
Cytolytic activity of the MBM13 and MBM15 T cell clones against a panel of HLA-typed EBV-LCL
| Name | HLA class I | HLA class II* | MBM15 | MBM13 |
|---|---|---|---|---|
| % specific lysis
(3:1)†
| ||||
| BM | A1 A2 B7 B57 Cw6 Cw7 | DR7 DR13 DQ2 DQ1 | ++ | ++ |
| M | A1 B7 B44 Cw7 Cw16 | DR7 DR13 DQ2 DQ1 | < | < |
| PH | A2 B62 Cw2 Cw3 | DR11 DR7 DQ2 DQ7 | ++ | ++ |
| JY | A2 B7 Cw7 | DR4 DR13 DQ1 DQ3 | ++ | ++ |
| WO | A1 A3 B35 B57 Cw4 Cw6 | DR101 DR4 DQ5 DQ8 | ++ | < |
| LE | A1 A3 B7 B44 Cw7 | DR15 DR11 DQ1 DQ7 | < | < |
| TS | A3 B7 B35 Cw4 Cw7 | DR11 DQ6 | < | < |
| BA | A1 A3 B7 B8 Cw7 | DR15 DR3 DQ1 DQ2 | < | < |
| GU | A1 A24 B13 B57 Cw6 | DR3 DR7 DQ2 DQ3 | < | < |
| SC | A3 A24 B35 Cw4 | DR101 DR13 DQ5 DQ6 | ++ | < |
| FO | A3 A24 B44 B61 Cw2 | DR101 DR4 DQ1 DQ7 | ++ | < |
| WT | A11 B35 Cw4 | DR101 DQ5 | ++ | < |
| LW | A33 B14 Cw8 | DR102 DQ5 | < | < |
| MZ | A24 B14 Cw2 Cw8 | DR102 DQ5 | < | < |
*
The HLA-DR1 subtyping was molecular defined.
†
Cytotoxic activity was marked with < when the percentage-specific lysis of the target cells was <10% at an E/T of 3:1. Cytotoxic activity was marked with ++ when the percentage-specific lysis of the target cells was >20% at an E/T of 3:1.