Table 4.
TLR9haplotypes and severity variables in meningococcal meningitis patients (p < 0.05)
| Severity variable | TLR9 haplotype¹ N (%) |
P | OR | 95% | CI | ||||
|---|---|---|---|---|---|---|---|---|---|
| |
I |
II |
III |
IV |
Total |
|
|
|
|
|
TLR9-1237 |
T |
T |
C |
C |
2 N |
|
|
|
|
|
TLR9 + 2848 |
G |
A |
A |
G |
|
|
|
|
|
|
N. meningitidis in blood culture |
|
|
|
|
|
|
|
|
|
| Positive |
162 (51)** |
119 (38) |
33 (10) |
2 (1) |
316 |
0.001 |
1.5 |
(1.1 2.0) |
– |
| Negative |
148 (41)** |
147 (41) |
59 (16) |
4 (1) |
358 |
|
|
|
|
| Total |
310 |
266 |
92 |
6 |
674 |
|
|
|
|
| CSF leukocytes per μL |
|
|
|
|
|
|
|
|
|
| ≤ 1000 |
164 (50)* |
122 (38) |
36 (11) |
2 (1) |
324 |
0.03 |
0.7 |
(0.5 1.0) |
– |
| >1000 |
154 (42)* |
144 (40) |
60 (17) |
4 (1) |
362 |
|
|
|
|
| Total | 31 | 266 | 96 | 6 | 686 |
¹ haplotypes as defined by Lazarus et al. [12].
* = significance p < 0.05. ** = significance p < 0.01.
Abbreviations: TLR: Toll-like receptor CSF: cerebrospinal fluid, OR: odds ratio.
Different numbers within groups are due to missing or non determined data in patient records.