Skip to main content
. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: J Neurochem. 2012 Jun 7;122(2):308–320. doi: 10.1111/j.1471-4159.2012.07790.x

Figure 1.

Figure 1

DA induces dose-dependent and bidirectional effects in GABAA receptor-mediated IPSCs in PFC layer 5 pyramidal neurons. A, Representative traces showing IPSCs induced by a 20-Hz 10-pulse train before (gray) and 10 min after (black) bath-application of DA at two different concentrations. B, Summary graph shows the effects of DA on the amplitudes of the first IPSCs during application of DA for 10 min. The open circles denote the first IPSC amplitude of individual neurons, whereas the closed triangles represent the average changes of the first IPSC amplitudes at each concentration of DA. DA induced bidirectional effects on evoked IPSCs, with a significant enhancement at the lower concentration of 200 nM but with suppression at the higher concentration of 20 μM (*p < 0.05, **p < 0.01).