Skip to main content
. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Kidney Int. 2012 Jun 13;82(8):878–891. doi: 10.1038/ki.2012.224

Figure 8. A schematic proposed cellular mechanisms of renal protection with A1AR.

Figure 8

Our data suggest that selective A1AR activation results in increased HIF-1α mRNA synthesis, increased HIF-1α nuclear translocation and SK1 induction with subsequent S1P1R activation. Consistent with this hypothesis, selective blockade of SK1 or S1P1R inhibits the renal protective effects of A1AR activation. Furthermore, a selective ABCC1 transporter inhibitor (MK571) would prevent the export of intracellular S1P to bind to extracellular S1P1R. Indeed, MK571 prevented the renal protective effects of an A1AR selective agonist (CCPA).