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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Oral Pathol Med. 2012 Jun 5;42(1):66–72. doi: 10.1111/j.1600-0714.2012.01181.x

Figure 3. IL-6 contributes towards the loss of salivary gland function.

Figure 3

Mice deficient in IL-6, IL-10 and IL27B, were either injected with poly(I:C) or PBS and pilocarpine induced saliva measured. The mean saliva volume in all groups of poly(I:C) treated mice are significantly lower than the mean saliva volumes in respective PBS treated controls. Saliva collections in IL-6−/− mice were done at 2 time points (12wks and 30wks of age) and the loss in function was 26% and 21% respectively. The loss of function in IL-27−/− (35%) IL-10−/− (38%) mice was comparable to that observed in wild type mice (41%). Similar results were obtained in an additional experiment.