Table 10.

Variation Between Temporomandibular Disorder (TMD) Cases and Controls in Medical Conditions Measured Categorically

Putative Risk Factor	Category	Controls		TMD Cases		P Value†	Site-Adjusted Effect‡		Fully-Adjusted Effect‡
		N	Column %	N	Column %		OR§	95% CI¶	OR	95% CI
History of 3 endocrine conditions#	1 or more	50	3.1	4	2.2	.4974	.7	.3, 2.0	.5	.2, 1.4
	0 [ref]*	1,578	96.9	180	97.8
History of 7 cardiovascular conditions#	1 or more	76	4.7	15	8.2	.0418	1.9	1.0, 3.3	1.5	.8, 2.8
	0 [ref]	1,545	95.3	169	91.8
History of 3 hematologic conditions#	1 or more	126	7.7	26	14.2	.0028	1.9	1.2, 3.0	1.3	.8, 2.0
	0 [ref]	1,500	92.3	157	85.8
History of 4 neural/sensory conditions#	1 or more	374	23.0	106	57.9	<.0001	4.7	3.4, 6.4	3.7	2.6, 5.2
	0 [ref]	1,254	77.0	77	42.1
History of 5 respiratory conditions#	1 or more	626	38.5	122	66.7	<.0001	3.1	2.3, 4.3	2.5	1.7, 3.4
	0 [ref]	1,000	61.5	61	33.3
History of obstructive sleep apnea	Yes	37	2.4	11	6.3	.0026	3.2	1.6, 6.4	3.1	1.4, 6.7
	No [ref]	1,530	97.6	164	93.7
History of osteoarthritis⧧	Yes	11	.7	5	2.7
	No [ref]	1,616	99.3	179	97.3
History of rheumatoid arthritis⧧	Yes	7	.4	3	1.6
	No [ref]	1,620	99.6	181	98.4
History of Sjogrens syndrome⧧	Yes	1	.1	1	.5
	No [ref]	1,627	99.9	182	99.5

^*Reference group used to calculate odds ratios.

^†P value is from binary logistic regression model evaluating overall association between putative risk factor and case status.

^‡Site-adjusted effects were computed in logistic regression models where the putative risk factor is the main explanatory variable and study site is the covariate. Fully-adjusted effects were computed in logistic regression models that additionally include covariates of age group, gender, and race/ethnicity.

^§Odds ratio.

^¶95% confidence interval for OR.

^#See Methods for the particular conditions included in this category.

^⧧P value and ORs not computed due to cells having expected frequencies of <5.