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Immunodetection of mTOR/HIF-1α downstream targets in control and mTOR-RR expressing HNSCC xenografts following rapamycin treatment. Immunohistochemistry was performed on tissue sections using antibodies against pS6, HIF-1α, Glut-1 and VEGF to determine the effects of rapamycin. pS6 and VEGF protein were mainly localized in cytoplasm. HIF-1α was localized in nuclei of tumor cells. Glut-1 is visible at the cell membrane and cytoplasm.
