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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Biochem J. 2012 Oct 1;447(1):149–157. doi: 10.1042/BJ20120609

Figure 1.

Figure 1

Levels of sphingolipids and compound SLR080811 in U937 treated with various concentrations of compound SLR080811 as indicated. After a 2 hour period of exposure, cells were harvested by centrifugation, lysed and the amounts of sphingolipids and SLR080811 in the lysates were measured by LC-MS as described in the Methods section. Amounts associated with cells are expressed as the number of pmoles per million cells. a: S1P; b: sphingosine; c: dihydroS1P; d: sphinganine: e: SLR080811. Data are presented as means ±SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 (one way ANOVA, and Bonferroni’s Multiple Comparison Test, compared to vehicle alone).