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. Author manuscript; available in PMC: 2013 Aug 23.
Published in final edited form as: J Med Chem. 2012 Aug 13;55(16):7141–7153. doi: 10.1021/jm300603y

Scheme 3.

Scheme 3

Synthesis of compounds for exploring the central linker.a

a Reagents and conditions: (a) K2CO3, EtOH, reflux, overnight, 35–80%; (b) NaI/K2CO3, CH3CN, reflux, 6 h, 40–70%; (c) Et3N, CH3CN, reflux, 4 h, 70–75%; (d) CuCl, Cs2CO3, TMHD, NMP, 120 °C, 7.5 h, 40–50%.