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SFSR of the middle amino moiety.a
| ||||||
|---|---|---|---|---|---|---|
| Cmpd | Middle Amino Moiety | D2R Ki (nM) | β-arrestin | cAMP | ||
| EC50 (nM) | Emax (%) | EC50 (nM) | Emax (%) | |||
| 1 |
|
3.9 | 4.0 | 62 | 1.0 | 51 |
| 18 |
|
11 | 2.0 | 70 | 363 | 80 |
| 19 |
|
3.6 | 2.0 | 41 | N/A | < 20 |
Ki, EC50, and Emax values are the average of at least 2 duplicate experiments with standard deviations (SD) values that are 3-fold less than the average.
