Skip to main content
. Author manuscript; available in PMC: 2013 Aug 23.
Published in final edited form as: J Med Chem. 2012 Aug 13;55(16):7141–7153. doi: 10.1021/jm300603y

Table 5.

SFSR of combination compounds.a

Cmpd Structure D2R Ki (nM) β-arrestin cAMP
EC50 (nM) Emax (%) EC50 (nM) Emax (%)
35 graphic file with name nihms398386t18.jpg 42 79 78 N/A < 20
36 graphic file with name nihms398386t19.jpg 75 50 97 N/A < 20
37 graphic file with name nihms398386t20.jpg 30 126 88 N/A < 20
38 graphic file with name nihms398386t21.jpg 20 63 71 N/A < 20
39 graphic file with name nihms398386t22.jpg 18 25 36 N/A < 20
40 graphic file with name nihms398386t23.jpg 11 20 80 N/A 32
41 graphic file with name nihms398386t24.jpg 104 200 78 N/A < 20
42 graphic file with name nihms398386t25.jpg 18 20 84 N/A < 20
43 graphic file with name nihms398386t26.jpg 5.7 6.3 41 N/A < 20
44 graphic file with name nihms398386t27.jpg 1.2 1.6 47 N/A < 20
45 graphic file with name nihms398386t28.jpg 3.4 2.5 49 N/A < 20
a

Ki, EC50, and Emax values are the average of at least 2 duplicate experiments with standard deviations (SD) values that are 3-fold less than the average.