TABLE 1.

Types of reactive lesions in lymph nodes of rodents.

Anatomical region	Sub-anatomical region/cell type/compartment	Cell loss	Increase in cells (hyperplasia)	Neoplasia
Entire LN	All	Atrophy	Lymphoid hyperplasia	Lymphoma
Cortex	Subcapsular sinuses	N/A	Histiocytic hyperplasia	Histiocytic sarcoma
	Follicles	Atrophy	Hyperplasia	Follicular or lymphoblastic lymphoma
	Germinal centers	Atrophy	Hyperplasia	Follicular or lymphoblastic lymphoma
	Interfollicular areas	Atrophy	Hyperplasia	N/A
Paracortex	Lymphocytes	Atrophy	Hyperplasia	Lymphoma
	Interdigitating cells (IDC)	N/A	Hyperplasia	IDC Sarcoma
	High endothelial venules	N/A	Hypertrophy or Hyperplasia	N/A
Medulla	Medullary cords	Atrophy	Hyperplasia	N/A
	Sinuses	Atrophy	hyperplasia	Histiocytic sarcoma

N/A, not applicable or not usually observed.