TABLE 3.

Stepwise histopathological analysis of the lymph nodes, spleen, and thymus.

1. Note gross appearances of all lymph nodes, spleen, thymus, and other lymphoid tissues.

2. Review histologically, at low magnification, the anatomy and histology.

3. Compare the anatomy and histology with normal tissues.

4. Review anatomical compartments for size compared to normal and relationships to other compartments.

5. Review cytology of cells in each compartment, comparing to normal cell types, and increase or decrease in compartment cellularity.

6. Use immunohistochemistry as an adjunct.

7. Compare with immunology techniques for interpretation.