TABLE 1.

Model Fit Statistics

Caffeine phenotype	Psychiatric phenotype	−2LL	df	Δdf	Δχ2	AIC	p-value
Caffeine use	GAD	10716.00	3926	n/a	n/a	2864.00	n/a
	GAD, no rg	10737.45	3927	1	21.45	2883.45	.00
	GAD, no re	10716.31	3927	1	0.31	2862.31	.58
	PAN	9821.36	3808	n/a	n/a	2205.36	n/a
	PAN, no rg	9824.26	3809	1	2.91	2206.26	.09
	PAN, no re	9823.20	3809	1	1.84	2205.20	.17
	PHO	11020.66	3926	n/a	n/a	3168.66	n/a
	PHO, no rg	11027.04	3927	1	6.38	3173.04	.01
	PHO, no re	11020.67	3927	1	0.01	3166.67	.91
	MDD	11003.75	3927	n/a	n/a	3149.75	n/a
	MDD, no rg	11022.08	3928	1	18.33	3166.08	.00
	MDD, no re	11007.66	3928	1	3.90	3151.66	.05
	AN	9045.16	3926	n/a	n/a	1193.16	n/a
	AN, no rg	9045.32	3927	1	0.16	1191.32	.69
	AN, no re	9045.22	3927	1	0.07	1191.22	.80
	BN	9283.82	3927	n/a	n/a	1429.82	n/a
	BN, no rg	9284.26	3928	1	0.44	1428.26	.51
	BN, no re	9284.16	3928	1	0.34	1428.16	.56
Tolerance	GAD	3921.97	3917	n/a	n/a	−3912.03	n/a
	GAD, no rg	3923.75	3918	1	1.78	−3912.25	.18
	GAD, no re	3923.59	3918	1	1.62	−3912.41	.20
	PAN	2999.51	3799	n/a	n/a	−4598.49	n/a
	PAN, no rg	3001.12	3800	1	1.61	−4598.88	.20
	PAN, no re	3000.22	3800	1	0.71	−4599.78	.40
	PHO	4197.50	3917	n/a	n/a	−3636.50	n/a
	PHO, no rg	4198.49	3918	1	0.99	−3637.51	.32
	PHO, no re	4199.59	3918	1	2.09	−3636.41	.15
	MDD	4217.70	3918	n/a	n/a	−3618.30	n/a
	MDD, no rg	4217.92	3919	1	0.23	−3620.08	.63
	MDD, no re	4223.08	3919	1	5.38	−3614.92	.02
	AN	2215.14	3917	n/a	n/a	−5618.86	n/a
	AN, no rg	2220.07	3918	1	4.92	−5615.93	.03
	AN, no re	2215.58	3918	1	0.44	−5620.42	.51
	BN	2456.71	3918	n/a	n/a	−5379.29	n/a
	BN, no rg	2462.58	3919	1	5.87	−5375.42	.02
	BN, no re	2459.87	3919	1	3.15	−5378.13	.08
Withdrawal	GAD	3579.07	3238	n/a	n/a	−2896.93	n/a
	GAD, no rg	3581.30	3239	1	2.23	−2896.70	.14
	GAD, no re	3579.18	3239	1	0.10	−2898.82	.75
	PAN	2652.58	3120	n/a	n/a	−3587.42	n/a
	PAN, no rg	2652.71	3121	1	0.13	−3589.29	.72
	PAN, no re	2652.93	3121	1	0.35	−3589.07	.55
	PHO	3857.32	3238	n/a	n/a	−2618.68	n/a
	PHO, no rg	3857.56	3239	1	0.25	−2620.44	.62
	PHO, no re	3858.68	3239	1	1.37	−2619.32	.24
	MDD	3876.13	3239	n/a	n/a	−2601.87	n/a
	MDD, no rg	3877.68	3240	1	1.55	−2602.32	.21
	MDD, no re	3876.69	3240	1	0.56	−2603.31	.45
	AN	1872.02	3238	n/a	n/a	−4603.98	n/a
	AN, no rg	1872.50	3239	1	0.48	−4605.50	.49
	AN, no re	1872.06	3239	1	0.04	−4605.94	.84
	BN	2112.09	3239	n/a	n/a	−4365.91	n/a
	BN, no rg	2113.45	3240	1	1.36	−4366.55	.24
	BN, no re	2112.12	3240	1	0.03	−4367.88	.85

Note: AIC = Akaike’s information criterion; GAD = generalized anxiety disorder; PAN = panic disorder; PHO = phobia; MDD = major depressive disorder; AN = anorexia nervosa; BN = bulimia nervosa; −2LL = −2 log-likelihood; n/a = not applicable; r_g = genetic correlation; r_e = environmental correlation.