. Author manuscript; available in PMC: 2013 May 1.

Published in final edited form as: Drug Discov Today. 2011 Dec 20;17(9-10):514–521. doi: 10.1016/j.drudis.2011.12.013

Table 1.

Current regimens for LTBI

Drugs	Dose (mg)	Duration	Frequency	Comment
INH	300	6–9 months	Daily	Standard 1^st line in HIV−/HIV+
INH	300	36 months	Daily	Recent evidence for greater efficacy in HIV+
INH	900	6–9 months	Twice weekly	Alternative regimen- allows directly observed therapy
RIF	600	4 months	Daily	Alternative regimen
RIF+INH	600+300	3 months	Daily	Alternative regimen
RPE+INH	900+900	3 months	Once weekly	Recently reported as effective in HIV+ and HIV−
RIF+PZA	600+2000	2 months	Daily	Hepatotoxicity issues in HIV−ve - no longer routinely recommended

INH = Isoniazid, RIF = Rifampicin, PZA = Pyrazinamide, RPE = Rifapentine,