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. Author manuscript; available in PMC: 2012 Sep 17.
Published in final edited form as: Mol Cell. 2011 Jan 7;41(1):46–55. doi: 10.1016/j.molcel.2010.12.008

Figure 3. APLF is a histone chaperone.

Figure 3

A, APLF facilitates chromatin assembly in a plasmid supercoiling assay in the presence of core histones and topoisomerase I. B, APLF assists CHD1 chromatin remodeler in chromatin formation as demonstrated by the appearance of a characteristic regularly spaced ladder of DNA fragments generated after partial nuclease digestion of the chromatin. C, APLF promotes chromatin disassembly by removing the histones from a tetrasome and leading to exposure of naked DNA. D and E, APLF has no effect on nucleosome or naked DNA substrates.