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. Author manuscript; available in PMC: 2012 Sep 17.
Published in final edited form as: Mol Cell. 2011 Jan 7;41(1):46–55. doi: 10.1016/j.molcel.2010.12.008

Figure 6. APLF homologues and analogues in lower eukaryotes.

Figure 6

A, Domain structures of the slime mold XRCC1 and the putative DNA repair factors containing zf-PARP DNA break sensor domain (named by accession numbers). Note that only acidic domain in XRCC1 of slime molds is homologous to APLF. B, Western-blot showing that immunoprecipitated C.elegans zf-PARP protein CeLig3 binds to histones independently of poly(ADP-ribosyl)ation. C, Recruitment of GFP-tagged CeLig3 to the sites of laser-induced DNA damage is dependent on active poly(ADP-ribose) synthesis.