Figure 5.

Simulations of the time courses of the relative populations of the Na⁺,K⁺-ATPase in the conformational states E1, E2, E1P, and E2P after a jump in the cytoplasmic Na⁺ concentration from 15 to 150 mM. All other conditions ([Na⁺]_ext = 140 mM, [K⁺]_cyt = 120 mM, [K⁺]_ext = 4 mM, [ATP]_cyt = 3 mM, V_m = −80 mV, T = 24°C) were held constant. The simulations were based on the kinetic and equilibrium parameters given in Table 1.