Figure 4.

Zn²⁺ inhibits the pore activity of freshly dissolved Aβ_1-40. The graph shows the influx of Ca⁺² (red line) and Zn²⁺ (blue line) ions induced by Aβ_1-40 on 0.2 mg/ml TLBE LUVs. Freshly dissolved Aβ_1-40 was added to each sample at time zero, and Ca⁺² or Zn⁺² was added at 600 s as indicated by the dashed line. Fura-2 is sensitive to both Ca⁺² and Zn²⁺ ions, as indicated by the control membrane disruptive MSI-78 peptide (Fig. S4).