TABLE 1.
CLINICAL CHARACTERISTICS OF STUDY SUBJECTS INCLUDED IN ANALYSIS
| Normal Subjects |
Subjects with Asthma |
|||||
| Weight/Asthma Status | Lean (n = 23) | Overweight/Obese (n = 23) | Lean (n = 17) | Overweight/Obese (n = 25) | ||
| P Value | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | ||
| Age, yr | O | 0.004 | 26.9 (6.6) | 33.2 (11.1) | 25.82 (8.6) | 32.8 (12.1) |
| A | 0.87 | |||||
| O–A | 0.71 | |||||
| Sex, male:female | O | 0.55 | 10M:13F | 7M:16F | 6M:11F | 9M:16F |
| A | 0.92 | |||||
| O–A | 0.51 | |||||
| Race | O | 0.0012 | 16 White | 8 White | 13 White | 16 White |
| A | 0.39 | 5 Black | 15 Black | 2 Black | 9 Black | |
| O–A | 0.99 | 2 Asian | 2 Asian | |||
| BMI, kg/m2 | O | 0.0001 | 22.8 (1.4) | 32.4 (4.4) | 21.4 (1.86) | 33.9 (9.4) |
| A | 0.61 | |||||
| O–A | 0.10 | |||||
| FEV1, L | O | 0.034 | 3.69 (0.76) | 3.24 (0.64) | 3.21 (0.77) | 2.97 (0.82) |
| A | 0.022 | |||||
| O–A | 0.54 | |||||
| FEV1, % | O | 0.22 | 102.2 (14.0) | 98.4 (9.1) | 88.7 (15.6) | 85.3 (15.1) |
| A | <0.0001 | |||||
| O–A | 0.93 | |||||
| FEV1/FVC ratio | O | 0.39 | 82.4 | 79.8 | 74 | 73.7 |
| A | <0.0001 | |||||
| O–A | 0.54 | |||||
| Methacholine PC20 | O | 0.81 | >16 | >16 | 0.97 (1.4) | 0.99 (1.7) |
| A | <0.001 | |||||
| O–A | 0.72 | |||||
| Number of subjects with allergic rhinitis | O | 0.48 | 3/23 | 5/23 | 17/17 | 22/25 |
| A | <0.0001 | |||||
| O–A | 0.12 | |||||
| Number of subjects receiving ICS | O | N/A | N/A | N/A | 0/17 | 1/25 |
| A | N/A | |||||
| O–A | N/A | |||||
| Number of subjects with GERD | O | 0.11 | 1/23 | 3/23 | 2/17 | 7/25 |
| A | 0.19 | |||||
| O–A | 0.88 | |||||
Definition of abbreviations: BMI = body mass index; F = female; GERD = gastroesophageal reflux disease; ICS = inhaled corticosteroids; M = male; N/A = not applicable; methacholine PC20 = provocative concentration of methacholine causing a 20% fall in FEV1.
Variables included in the analysis include weight (O) and asthma (A) with an interaction term (O–A). Bold type represents statistical significance.