TABLE 2.
CHARACTERISTICS OF SUBJECTS INCLUDED IN MACROPHAGE EXPERIMENTS
| Normal Subjects |
Subjects with Asthma |
|||||
| Weight/Asthma Status | P Value | Lean (n = 5) | Overweight/Obese (n = 4) | Lean (n = 5) | Overweight/Obese (n = 8) | |
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |||
| Age, yr | O | 0.53 | 28.6 (8.6) | 28 (2.0) | 24.33 (2.5) | 30 (10.6) |
| A | 0.78 | |||||
| O–A | 0.44 | |||||
| Sex, male:female | O | 0.95 | 2M:3F | 1M:3F | 0M:5F | 3M:5F |
| A | 0.95 | |||||
| O–A | 0.94 | |||||
| Race | O | 0.97 | 4 White | 2 White | 3 White | 3 White |
| A | 0.98 | 1 Asian | 2 Asian | 2 Black | 5 Black | |
| O–A | 0.98 | |||||
| BMI, kg/m2 | O | 0.0004 | 22.6 (1.4) | 29.94 (3.7) | 20.8 (1.21) | 35.1 (8.6) |
| A | 0.51 | |||||
| O–A | 0.18 | |||||
| FEV1, L | O | 0.74 | 3.61 (0.76) | 3.41 (0.2) | 3.1 (0.48) | 3.13 (0.56) |
| A | 0.12 | |||||
| O–A | 0.64 | |||||
| FEV1, % | O | 0.82 | 102.3 (12.7) | 101.5 (9.1) | 93.3 (6.12) | 93.4 (10.5) |
| A | 0.62 | |||||
| O–A | 0.68 | |||||
| FEV1/FVC ratio | O | 0.61 | 88.9 | 84.2 | 76.7 | 78.3 |
| A | <0.008 | |||||
| O–A | 0.31 | |||||
| Methacholine PC20 | O | 0.14 | >16 | >16 | 3.02 (2.7) | 1.1 (0.9) |
| A | <0.001 | |||||
| O–A | 0.14 | |||||
Definition of abbreviations: BMI = body mass index; methacholine PC20 = provocative concentration of methacholine causing a 20% fall in FEV1.
Variables included in the analysis include weight (O) and asthma (A) with an interaction term (O–A). Bold type represents statistical significance.