TABLE 5.

ASSESSMENT OF MICROVASCULAR BLOOD FLOW AND ENDOTHELIAL FUNCTION IN TYPE 2 DIABETES WITH AND WITHOUT OBSTRUCTIVE SLEEP APNEA

	OSA− (n = 24)	OSA+ (n = 47)	P Value, Unadjusted	P Value, after Adjustment
Conductance
Baseline	0.40 (0.28–0.48)	0.20 (0.16–0.31)	<0.001	<0.001
Heating	1.82 (1.43–2.03)	1.66 (1.28–2.07)	0.37	0.42
Ach	1.43 (1.09–1.83)	1.07 (0.75–1.29)	0.002	0.1
SNP	1.61 (1.15–2.14)	1.16 (0.62–1.41)	0.001	<0.001
Flux in relation to maximum vasodilatation
Baseline	0.22 (0.16–0.29)	0.14 (0.10–0.17)	<0.001	0.002
Ach	0.81 (0.670.902)	0.63 (0.430.77)	0.005	0.26
SNP	0.93 (0.77–1.13)	0.57 (0.41–0.89)	<0.001	0.001

Definition of abbreviations: Ach = acetylcholine; IQR = interquartile range; OSA = obstructive sleep apnea; SNP = sodium nitroprusside.

Data presented as median (IQR) or ratios. Blood flux was measured in arbitrary perfusion units. Conductance is calculated by dividing flux by the mean arterial pressure. Analysis was performed using the Mann-Whitney U test. Adjusted P values were calculated using linear regression. For patient characteristics please refer to Tables E5 and E6 in the online supplement. For the results of the adjusted analysis using forced entry method please refer to Table E7 in the online supplement.