TABLE 4.

TOP SINGLE-NUCLEOTIDE POLYMORPHISMS WITHIN SIGNATURE GENES ASSOCIATED WITH ELEVATED TRICUSPID REGURGITATION JET VELOCITY

SNP	Signature Gene	Ref Allele	P Value	P Value*	OR	Freq SCD High TRV Cases	Freq SCD Control	Freq ASW	Function
rs799813	GALNT13	C	0.001	0.002	0.28	0.094	0.27	0.25	Intronic
rs2794452	PRELP	C	0.001	0.013	0.42	0.34	0.55	0.58	Upstream
rs10497120	GALNT13	C	0.001	0.001	2.76	0.33	0.15	0.13	Upstream
rs13407922	GALNT13	A	0.002	0.003	3.08	0.24	0.095	0.14	Intronic
rs16833378	GALNT13	G	0.003	0.003	0.26	0.061	0.20	0.11	Upstream
rs9808145	GALNT13	A	0.004	0.006	2.97	0.22	0.089	0.13	Intronic

Definition of abbreviations: ASW = African ancestry from Southwest United States; Freq = frequency; OR = odds ratio; Ref = reference; SCD = sickle cell disease.

^*Adjusted for cohort.