Table 2.
Comparison of the deduced primary structures and surface expression profiles of KIR2DL5 alleles.
| 2DL5 allele | Leader peptide exons 1–2 |
D0 domain exon 3 |
D2 domain exon 5 |
Stem exon 7 |
Cyt. exon 9 |
Surface expression detectable with UP-R1* | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| −16 Ile | −1 Thr | 16 Ala | 78 His | 95 Val | 114 Arg | 152 Asn | 167 Gly | 174 Gly | 215 Arg | 284 Val | ||
| A*001 | – | – | – | – | – | – | – | – | – | – | – | Yes |
| B*008 | Val | – | – | – | – | – | – | – | – | – | – | na |
| A*012 | – | Pro | – | – | – | – | – | – | – | – | – | (Yes) |
| B*006 | Val | Pro | – | – | – | – | – | – | – | – | – |  |
| A*015 | – | – | – | – | – | Cys | – | – | – | – | – | ? |
| B*013 | Val | – | – | – | – | Cys | – | – | – | – | – | na |
| A*005 | – | – | – | – | – | – | Asp | – | Ser | – | – | No |
| B*002 | Val | – | – | – | – | – | Asp | – | Ser | – | – | na |
| A*014 | – | – | – | – | – | – | – | Arg | – | – | – | ? |
| B*004 | Val | – | Thr | – | – | – | – | – | – | – | – | na |
| B*007 | Val | – | – | – | Met | – | – | – | – | – | – | na |
| B*003 | Val | Pro | – | – | Met | – | – | – | – | – | – | ? |
| B*011 | Val | Pro | – | – | – | – | – | – | – | – | Ile | na |
| B*009 | Val | – | – | – | – | – | Asp | – | Ser | Leu | – | na |
| B*010 | Val | Pro | – | – | – | – | Asp | – | Ser | – | – | na |
| B*016 | Val | – | – | Tyr | – | – | Asp | – | Ser | – | – | na |
*Yes: surface expression demonstrated by flow cytometry with UP-R1; No: lack of staining with UP-R1 demonstrated in KIR2DL5A*005 cells; (Yes): surface expression and staining with UP-R1 is predictable, according to the allele primary structure and promoter type, but has not been assessed; ?: surface expression and staining with UP-R1 can not be predicted in a transcribed allele, due to polymorphisms in the ectodomain; na: not applicable due to demonstrated or likely lack of transcription; (Yes)/na: different variants of allele KIR2DL5B*006 have functional or non-functional promoters (Table 3). KIR2DL5A alleles are shown in 
, and KIR2DL5B ones, in 
. Allele order has been arranged to highlight patterns of homology between alleles.