Table 3.
Comparison of the proximal promoter sequences and transcription profiles of KIR2DL5 alleles.
| KIR2DL5 allele | Promoter region |
Promoter type | Transcription | |||||
|---|---|---|---|---|---|---|---|---|
| −104 G | −97 G | −84 A | −27 C | −23 C | −10 C | |||
| A*0010101–00105 | – | – | – | – | – | – | I | + |
| A*0050101/03–04 | – | – | – | – | – | – | I | + |
| A*01201/02 | – | – | – | – | – | – | I | (+) |
| A*0050102 | A | – | – | – | – | – | I | (+) |
| B*0020101–03/05/07, *0070101 | A | A | G | – | T | – | II | − |
| B*004, *0080101/00802, *009, *01301/02 | A | A | G | – | T | – | II | − |
| B*00601/03 | A | A | G | – | – | – | II | − |
| B*0020104, *00202, *0080102, *010, *011 | A | A | G | – | – | – | II | (−) |
| B*003 | A | – | – | T | – | T | III | + |
| B*00602 | A | – | – | T | – | T | III | (+) |
Transcription of the alleles shown in bold face has been assessed experimentally; in parentheses are shown predictions for groups of alleles of which no member has been studied by RT-PCR. The promoter regions of KIR2DL5 alleles A*014, A*015, B*0020106, B*0070102, B*01303, and B*016 have not been sequenced.