Table 2. Outcome measures at baseline, 6 and 12 months.
| Baseline±SD | 6 months (change from baseline±SD, P-value) | 12 months (change from baseline) | ||||
|---|---|---|---|---|---|---|
| |
High-dose group (2.0 mg) |
Standard-dose group (0.5 mg) |
High-dose group (2.0 mg) |
Standard-dose group (0.5 mg) |
High-dose group (2.0 mg) |
Standard-dose group (0.5 mg) |
| Mean VA (ETDRS letters) | 63.7±8.5 | 61.5±14.8 | 69.9 (+6.1±3.7, W=0, P<0.001) | 63.5 (+2.0) | 67.9 (+4.1±4.5, W=4.5, 0.10<P<0.20) | 64.5 (+3.0) |
| Central foveal thickness (μm) | 325±108 | 397±192 | 285 (−40±38, W=0, P<0.001) | 289 (−108) | 297 (−28±46, W=5, 0.10<P<0.20) | 325 (−73) |
| ‘PED' (μm) | 100±68 | 156±101 | 102 (+2±35, W=13, P>0.20) | 73 (−83) | 108 (+8±48, W=13, P>0.20) | 85 (−71) |
| ‘SRF' (μm) | 122±113 | 94±49 | 73 (−50±75, W=1.5, 0.02<P<0.05) | 110 (+16) | 70 (−53±115, W=8, P>0.20) | 108 (+14) |
| ‘IRF' (μm) | 114±45 | 276±245 | 112 (−2±21, W=14, P>0.20) | 96 (−180) | 106 (−8±47, W=12, P>0.20) | 107 (−169) |
| Maximum PED height on the foveal scan (μm) | 222±126 | 237±53 | 169 (−52±82, W=1, 0.02<P<0.05) | 149 (−88) | 166 (−56±106, W=3, 0.05<P<0.10) | 143 (−94) |
| Maximum PED diameter on the foveal scan (μm) | 2399±818 | 3336±496 | 2310 (−89±192 W=7, P>0.20) | 3259 (−77) | 2145 (−254±260, W=3, 0.05<P<0.10) | 3033 (−304) |
| Presence of any sub-RPE fluid (number, (%)) | 7/7 (100%) | 2/2 (100%) | 7/7 (100%) | 2/2 (100%) | 7/7 (100%) | 2/2 (100%) |
| Presence of any SRF (number, (%)) | 7/7 (100%) | 2/2 (100%) | 4/7 (57%) | 1/2 (50%) | 5/7 (71%) | 1/2 (50%) |
| Presence of any IRF (number, (%)) | 1/7 (14%) | 1/2 (50%) | 2/7 (29%) | 1/2 (50%) | 4/7 (57%) | 1/2 (50%) |
| Area of leakage on fluorescein angiography (mm2) | 10.56±3.85 | 11.19±1.42 | 9.64 (−0.92±0.95, W=0, P<0.001) | 9.89 (−1.30) | 8.95 (−1.87±0.89, W=0, P<0.001) | 7.84 (−3.35) |
| Greatest linear diameter of leakage on fluorescein angiography (mm) | 4.40±0.73 | 4.22±0.31 | 4.14 (−0.26±0.39, W=3, 0.05<P<0.10) | 3.97 (−0.36) | 4.12 (−0.35±0.38, W=3, 0.10<P<0.20) | 3.89 (−0.44) |
| Mean number of injections (±SD) | N/A | N/A | 6.0 (±0.0) | 5.0 | 6.0 (±0.0) | 5.0 |
Abbreviations: IRF, intraretinal fluid; PED, pigment epithelial detachment; SRF, subretinal fluid; VA, visual acuity; ‘IRF', vertical height from inner segment/outer segment junction to internal limiting membrane at the fovea; ‘PED', vertical height from Bruch's membrane to top of retinal pigment epithelium at the fovea; ‘SRF', vertical height from top of retinal pigment epithelium to inner segment/outer segment junction at the fovea.