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. Author manuscript; available in PMC: 2013 Sep 14.
Published in final edited form as: Org Biomol Chem. 2012 Jul 25;10(34):6826–6829. doi: 10.1039/c2ob25962a

Table 1.

Reaction conditions screen

graphic file with name nihms-399720-t0007.jpg
Entry Pyrrolidine Pd cat (5 mol%) Temp. Time Conversion
1 0.5 equiv. Pd(PPh3)4 rt 24 h 50%
2 1.5 equiv. Pd(PPh3)4 rt 28 h 75%
3 1.5 equiv. Pd(PPh3)4 50 °C 16 h 90%
4a 1.5 equiv. Pd(PPh3)4 rt 16 h 50%
5b 1.5 equiv. Pd(PPh3)4 rt 28 h 0%
6c 1.5 equiv. Pd(PPh3)4 rt 28 h 40%
7 1.5 equiv. (η3-AllylPdCl)2,
Xantphos		 rt 24 h 50%
8 1.5 equiv. Pd(acac)2, DPPF rt 12 h 90%
a

1 equiv. of Et3N.

b

MeCN as solvent.

c

NMP as solvent.