Table 2.
Embryonic lethality of homozygous Ctr1 null mice
| Embryo or pups
|
Genotype
(%)
|
Resorbed (%) | |||
|---|---|---|---|---|---|
| Day | Number | +/+ | +/− | −/− | |
| 3 weeks | 378 | 140 (37%) | 238 (63%) | 0 (0%) | ND |
| E 12.5 | 132 | 30 (23%) | 63 (48%) | 0 (0%) | 39 (29%) |
| E 10.5 | 169 | 44 (26%) | 79 (47%) | 41 (24%) | 5 (3%) |
| E 8.5 | 138 | 33 (24%) | 70 (51%) | 28 (20%) | 7 (5%) |
Genotypes of offspring from Ctr1+/− intercrosses were determined by PCR and/or Southern blotting analysis of genomic DNA isolated from 3-week-old mice or embryos at the indicated stages post fertilization. ND, not determined.