Figure 3. ss-siRNAs and other oligonucleotides used in these studies.

N.I.: no inhibition; N/A: Not available. Except for CM (a dsRNA species), all T_m's are measured using ss-siRNAs duplexed with equimolar amounts of unmodified ssRNA 5'- CAGCAGCAGCAGCAGCAGCAGC-3'. Gapmer oligonucleotides have backbones containing only phosphorothioate linkages. All data were obtained using HD patient-derived fibroblast cell line GM04281. Selectivity is calculated by dividing the IC₅₀ of for inhibition of wild-type HTT expression by that for mutant HTT. Error ranges represent standard error of the mean (SEM) of IC₅₀ values from biological replicates.