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. Author manuscript; available in PMC: 2013 Aug 31.
Published in final edited form as: Cell. 2012 Aug 31;150(5):895–908. doi: 10.1016/j.cell.2012.08.002

Figure 6. Allele-selective inhibition of HTT by ssiRNA in Q150 HD mouse model.

Figure 6

(A) Western analysis of HTT expression on allele-selective inhibition by ss-siRNA 537775 (n=5) in Q150/Q7 mouse frontal cortex.

(B) Quantitation of wild-type and mutant HTT protein levels shown in (A).

(C) Q-PCR analysis of HTT mRNA levels in mouse frontal cortex after treatment with ss-siRNA, vehicle, or control gapmer ASO.

(D) Western analysis HTT expression after allele-selective inhibition by ss-siRNA 537773 (n=5) in different brain regions.

(E) Quantitation of western analysis from (D). Results from each treatment group/brain section were averaged.

Error bars represent standard error of the mean (SEM) after averaging quantitation results from multiple gel images. *p < 0.05; **p < 0.01; ***p < 0.001.

See also Figure S3.