Figure 5.
PI3K blockade recreates liver IRI in mice undergoing Ad-HO-1 gene transfer.
(A) The sGPT levels (IU/L). Mean±SD (n=4-6 samples/group). *p<0.05.
(B/C) Severity of liver IRI by Suzuki's histological scores. (a) DMSO control (3.16±0.41); (b) PI3K inhibitor LY294002 (3.67±0.52); (c) Ad-HO-1 (0.83±0.41); (d) LY294002+Ad-HO-1 (3.33±0.51). Representative of 4-6 mice/group; original magnification×200.
(D) Liver neutrophil accumulation (MPO activity; U/gm). Mean±SD; n=4-6 samples/group. *p< 0.05.