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. 2012 Sep 7;18:2338–2351.

Table 5. Gene set enrichment analyses (GSEA) of retinal expression in C57BL mice fed normal control diet (NCD), high fat diet (HFD) or bilberries (BB) in these diets for 12 weeks.

Limit1
 Term
 Count
 Fold enrichment
 p-value2
HFD versus NCD
upregulated (n=431, 2 unknown)
  
 Dilated cardiomyopathy
 7
 3.5
 0.01
  
 Hypertrophic cardiomyopathy (HCM)
 6
 3.3
 0.03
  
 MAPK signaling pathway
 11
 1.9
 0.06
down regulated (n=374, 3 unkwown)
  
 Apoptosis
 11
 6.2
 0
  
 Calcium signaling pathway
 10
 2.6
 0.02
  
 Melanogenesis
 6
 2.9
 0.05
  
 Long-term potentiation
 5
 3.5
 0.05
HFD+BB versus NCD
upregulated (n=395, 2 unknown)
  
 Systemic lupus erythematosus
 7
 3.5
 0.01
  
 Colorectal cancer
 6
 3.6
 0.02
down regulated (n=410, 3 unknown)
  
 Apoptosis
 10
 5
 0
  
 Calcium signaling pathway
 10
 2.3
 0.03
  
 Gap junction
 6
 3.2
 0.05
HFD+BB versus HFD:
upregulated (n=393, 1 unknown)
  
 Systemic lupus erythematosus
 7
 3.4
 0.02
down regulated (n=412, 4 unknown)
  
 Apoptosis
 9
 4.7
 0
NCD+BB versus NCD:
upregulated (n=416, 2 unknown)
  
 Systemic lupus erythematosus
 8
 3.6
 0.01
down regulated (n=389, 3 unknown)
  
 Apoptosis
 9
 5.1
 0
  
 MAPK signaling pathwway
 11
 2
 0.04
   Calcium signaling pathway 9 2.3 0.04

The gene expression enrichment results for KEGG pathways determined by over-representation analysis in DAVID.1 limits in search criteria up: p<0.05 AND LR> 0 OR down: LR<0 regulated probes. Log ratio (LR) determined by subtracting the denominator groups from numerator groups’ natural log-expression values. 
2 p values from F-test statistics with Bonferroni’s correction for multiple testing (DAVID).