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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 May 10;32(7):1577–1584. doi: 10.1161/ATVBAHA.112.251538

Figure 5.

Figure 5

Sms1−/− bone marrow transplanted Ldlr−/− mice (Sms1−/−→Ldlr−/−) on a western diet have reduced atherosclerotic plaques with less macrophage accumulation. Panel A, Aortic arches with atherosclerotic plaques (red arrows). Panel B, En face aortic plaque analysis after Oil Red O staining. Panel C, Quantitative display of en face assay. Panel D, Aortic root assay for proximal lesion areas after H&E staining. Panel E, Quantitative display of root assay. Panel F, immunohistochemical staining of macrophage accumulation in lesions (brown staining). Panel G, Quantitative display of macrophage content. Results are representatives of nine animals in each group. Quantifications were done by using Image J software. Values are mean ± SD, n=9, * P<0.01.