Table 1.
In vitro anti-malarial activities of drugs against chloroquine-susceptible (9A) and -resistant (K1) strains of Plasmodium falciparum
|
Drugs |
Mean IC50and 95% CI (μM) |
|
|---|---|---|
| P. falciparum K1 strain | P. falciparum 9A strain | |
| Quinine |
0.258 (0.242 - 0.275) |
0.398 (0.307 - 0.516) |
| Chloroquine |
0.873 (0.824 - 0.926) |
0.132 (0.082 - 0.211) |
| Clotrimazole |
0.805 (0.689 - 0.939) |
1.67 (1.18 – 2.37) |
| Pyrimethamine |
23.03 (18.36 - 28.90) |
Not done |
| Artemisinin | 0.139 (0.124 - 0.155) | 0.483 (0.376 - 0.622) |
Parasitized red blood cells were incubated with different concentrations of drugs for 72 hr and parasite growth was evaluated using the haemozoin-based colorimetric method. The IC50 and its 95% confidence interval (95% CI) were calculated from the concentration-response curve of the haemozoin level vs the log concentration of a drug