Table 2.
HR (95%CI) of all-cause death associated with BMI overall and by menopausal status
| |
BMI |
Patients |
Person-years |
All-cause death |
Age-adjusted |
|
Multivariate-adjusted |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | ||||||||
| All | |||||||||||
| |
|
<21.2 |
163 |
963.0 |
42 |
1.73 |
1.07 - 2.80 |
|
1.60 |
0.97 - 2.63 |
|
| |
|
≥21.2 to <23.3 |
166 |
1052.4 |
27 |
1.00 (reference) |
|
1.00 (reference) a |
|
||
| |
|
≥23.3 to <25.8 |
161 |
1020.1 |
29 |
1.03 |
0.61 - 1.75 |
|
0.88 |
0.51 - 1.51 |
|
| |
|
≥25.8 |
163 |
997.3 |
38 |
1.37 |
0.83 - 2.25 |
|
1.46 |
0.87 - 2.44 |
|
| |
p for trend |
|
|
0.35 |
|
|
0.59 |
||||
| |
p for trend in women with BMI ≥21.2 |
|
|
0.18 |
|
|
0.11 |
||||
| Premenopausal | |||||||||||
| |
|
<21.2 |
89 |
556.1 |
18 |
2.04 |
0.88 - 4.69 |
|
1.75 |
0.71 - 4.29 |
|
| |
|
≥21.2 to <23.3 |
73 |
510.2 |
8 |
1.00 (reference) |
|
1.00 (reference) b |
|
||
| |
|
≥23.3 to <25.8 |
63 |
391.6 |
11 |
1.74 |
0.70 - 4.35 |
|
1.61 |
0.63 - 4.11 |
|
| |
|
≥25.8 |
52 |
319.8 |
13 |
2.49 |
1.03 - 6.03 |
|
2.61 |
1.01 - 6.78 |
|
| |
p for trend |
|
|
0.52 |
|
|
0.29 |
||||
| |
p for trend in women with BMI ≥21.2 |
|
|
0.05 |
|
|
0.059 |
||||
| Postmenopausal | |||||||||||
| |
|
<21.2 |
67 |
371.6 |
20 |
1.56 |
0.82 - 2.98 |
|
0.93 |
0.47 - 1.86 |
|
| |
|
≥21.2 to <23.3 |
86 |
500.7 |
17 |
1.00 (reference) |
|
1.00 (reference) b |
|
||
| |
|
≥23.3 to <25.8 |
93 |
589.2 |
16 |
0.74 |
0.37 - 1.47 |
|
0.45 |
0.21 - 0.94 |
|
| |
|
≥25.8 |
108 |
670.7 |
22 |
0.93 |
0.49 - 1.75 |
|
0.72 |
0.36 - 1.45 |
|
| |
p for trend |
|
|
0.086 |
|
|
0.2 |
||||
| |
p for trend in women with BMI ≥21.2 |
|
|
0.91 |
|
|
0.71 |
||||
| Pre v Post p for heterogeneity of trends |
|
|
0.13 |
|
|
0.24 |
|||||
| Pre v Post p for heterogeneity of trends in women with BMI ≥21.2 | 0.09 | 0.11 | |||||||||
a Adjusted by age, stage (in situ or localized, lymph node metastasis, local invasion, distant metastasis, missing), hormone receptor (ER + or PgR+, ER-/PgR-, missing), radiation therapy (no, yes), chemotherapy (no, yes), endocrine therapy (no, yes), smoking (current, past, never, missing), family history of breast cancer in father, mother, brother or sister (no, yes), menopausal status (premenopausal, postmenopausal, missing), physical activity (almost no, more than one hour per week, missing) and comorbidities (no, yes).
b Adjusted by age, stage, hormone receptor, radiation therapy, chemotherapy, endocrine therapy, smoking, family history of breast cancer in father, mother, brother or sister, physical activity and comorbidities.
An increased risk of all-cause death was found among premenopausal women with BMI ≥25.8 kg/m2. Trend test for premenopausal women with BMI ≥21.2 kg/m2 also showed a marginal dose–response relationship.