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. 2012 May 18;13:74. doi: 10.1186/1471-2474-13-74

Table 4.

Top ten of most harmful (side effects) management strategies (0 = no harm; 10 = maximum harm)

Side effects
Order Management strategy N; Mean harm (0-10)(SD) * High harm (8-10)
N (%) *
1
Strong opioids
133; 5.4 (3.6)
49 (36.8)
2
Local cold therapy
367; 5.1 (4.1)
148 (40.3)
3
Anticonvulsants (Pregabalin, Gabapentin)
198; 5.0 (3.7)
69 (34.9)
4
Tramadol
365; 4.8 (3.6)
110 (30.1)
5
Transdermal opioids
115; 4.7 (3.8)
35 (30.4)
6
Duloxetine
192; 4.5 (3.7)
56 (29.2)
7
Amitriptyline
598; 4.5 (3.5)
157 (26.3)
8
Tramadol combined with paracetamol
82; 4.3(3.7)
20 (24.4)
9
Tilidine
262; 4.3 (3.5)
65 (24.8)
10 Whole body cold therapy 244; 4.1 (4.2) 79 (32.4)

* Note: The discrepancies between the number of persons in the different rows are due to missing items.

The ratings of side effects of all management strategies are available on request.