FIG. 1.

Amino acid variability at each site of HIV-2 protease for untreated individuals (A) and patients treated with protease inhibitor-containing regimen (B). The variability was considered to be the percentage of sequences that contained, at a given position, an amino acid that was not the most frequently found in the studied set of sequences. Amino acid positions of interest (highly variable or potentially associated with resistance to protease inhibitors) are in bold type. Hatched bars indicate positions thought to be associated with resistance to protease inhibitors.