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. 2012 Aug 1;11:89. doi: 10.1186/1475-2840-11-89

Table 2.

Hemodynamic parameters

 
 Condition
 Wild type
 Ob/ob
 DKO
    Sham IR Sham IR Sham IR
Heart rate (bpm)
 Untreated
 575 ± 40
 560±62
 526 ± 44a
 540±41
 523 ± 29a
 513±38
 
 Diet
  
  
 504 ± 30a
 500 ± 31
 503 ± 34a
 516±51
 
 ACE-I
 548 ± 33
 524 ± 36
 505 ± 29
 492±33
 499 ± 51
 509±68
Stroke volume (μl)
 Untreated
 16.2 ± 5.3
 6.8±3.2c
 14.8 ± 3.1
 12.0±4.3a
 10.1 ± 5.1a
 9.6±4.1
 
 Diet
  
  
 13.6 ± 6.0
 14.2±7.0a
 11.8 ± 5.1
 12.7±6.1a
 
 ACE-I
 16.5 ± 4.9
 8.1 ± 1.6c
 14.0 ± 3.2
 12.6±4.2a
 15.1 ± 6.1
 12.4±3.0a
Stroke work (mmHg*μl)
 Untreated
 1256 ± 328
 263±167c
 835 ± 189a
 509±181ac
 606 ± 269a
 409±199
 
 Diet
  
  
 804 ± 546
 667±336a
 627 ± 272a
 676±332a
 
 ACE-I
 877 ± 399
 369 ± 158c
 788 ± 251
 581±230
 780 ± 408
 563±170
Psys(mmHg)
 Untreated
 80.5 ± 18.2
 55.1±10.6c
 68.7 ± 7.5
 62.5±2.7
 69.5 ± 11.1
 62.7±10.6
 
 Diet
  
  
 68.4 ± 10.8
 60.4±5.9
 67.1 ± 12.6
 65.0±5.5a
 
 ACE-I
 62.9 ± 11.9
 61.9 ± 19.9
 67.9 ± 6.9
 59.2±7.5c
 61.4 ± 6.2
 56.1±8.1d
Ped(mmHg)
 Untreated
 3.0 ± 0.7
 2.9±1.2
 3.6 ± 0.7
 6.6±3.3ac
 4.8 ± 2.3a
 6.6±2.4a
 
 Diet
  
  
 3.0 ± 1.1
 4.3±1.2a
 3.8 ± 1.3
 4.3±1.5ab
 
 ACE-I
 3.6 ± 2.0
 2.9 ± 2.3
 4.5 ± 0.9d
 5.0±1.5
 3.7 ± 0.9
 3.4±1.5b
PRSW (mmHg)
 Untreated
 88.8 ± 5.5
 61.5 ± 11.6c
 64 ± 2.6a
 48.5 ± 3.3ac
 57.1 ± 4.6ae
 46.2 ± 8.8ac
 
 Diet
  
  
 65.4 ± 1.9a
 51 ± 1.9ac
 58 ± 2.8ae
 49.7 ± 3ac
 
 ACE-I
 87.4 ± 4.4
 60.2 ± 6.4c
 71.8 ± 3.2abd
 52.1 ± 3.4ac
 66.3 ± 5abde
 51.2 ± 3.4ac
Ees(mmHg/μl)
 Untreated
 8.3 ± 2.5
 6.4±1.5
 5.1 ± 0.4a
 4.7±1.5
 6.5 ± 2.4
 4.5±0.8a
 
 Diet
  
  
 6.6 ± 2.1
 4.5±1.1ac
 5.1 ± 1.2a
 5.3±1.2
 
 ACE-I
 6.0 ± 1.0
 6.8 ± 2.0
 5.5 ± 1.7
 4.6±1.7
 5.6 ± 1.3
 4.4±1.3a
Tau (ms)
 Untreated
 6.3 ± 1.2
 7.6±2.2
 6.2 ± 0.5
 6.4±1.0
 6.9 ± 0.9
 7.2±0.7
 
 Diet
  
  
 6.9 ± 0.5b
 7.7±0.8bc
 6.8 ± 0.6
 7.3±1.2
 
 ACE-I
 6.6 ± 1.5
 7.4 ± 1.5
 8.0 ± 1.1bd
 8.8±1.5b
 7.4 ± 0.8
 7.1±1.1e
EDPVR (mmHg/μl)
 Untreated
 0.2 ± 0.2
 0.4±0.2
 0.4 ± 0.3
 0.5±0.3
 0.6 ± 0.4a
 0.3±0.1
 
 Diet
  
  
 0.2 ± 0.2
 0.2±0.1
 0.2 ± 0.2
 0.2±0.1ab
 
 ACE-I
 0.2 ± 0.1
 0.4 ± 0.3
 0.4 ± 0.1
 0.3±0.1
 0.3 ± 0.1be
 0.3±0.1d
Ea(mmHg/μl)
 Untreated
 4.8 ± 1.5
 8.1 ± 2.4c
 4.0 ± 0.9
 5.0±2.0a
 6.8 ± 3.5
 5.6±1.8a
 
 Diet
  
  
 4.9 ± 1.8
 4.8±2.7a
 5.2 ± 2.2
 5.4±2.1a
  ACE-I 3.3 ± 0.6b 6.9 ± 1.3c 4.6 ± 1.5 4.5±1.5a 3.4 ± 1.3b 3.8±1.0ab

ACE-I: angiotensin-converting enzyme inhibition; DKO: double knock-out (ob/ob; LDLR-/-); Ea: arterial elastance; EDPVR: end-diastolic pressure-volume relationship; Ees: end-systolic elastance; IR: ischemia/reperfusion; Ped: end-diastolic pressure; Psys: systolic pressure “a” p < 0.05 versus WT same treatment, same condition (sham or IR); “b” p < 0.05 versus same untreated genotype, same condition (sham or IR); “c” p < 0.05 versus sham, same genotype, same treatment; “d” p < 0.05 versus diet, same genotype, same condition (sham or IR); “e” p < 0.05 versus ob/ob same treatment, same condition (sham or IR).