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Effect of treatment with sham or anti-HMGB1 antibodies on hepatocyte regeneration in acetaminophen (APAP)-injected mice. 5-bromo-2-deoxyuridine (BrdU) staining was assessed at 48 hours after induction of acute liver injury (ALI) (or sham procedure, n = 6 for each group). A typical picture is shown. BrdU-positive nuclei are indicated by arrows. (A = 48 h Control, B = 48 h Sham IgG, C = 48 h anti-HMGB1).
