Table 1.

Summary sensitivity and specificity based on bivariate model with no covariates

Data		Median Sensitivity (95% CI)[95% PI]	Median specificity (95% CI)[95% PI]	Heterogeneity SD on logit scale (sens)	Heterogeneity SD on logit scale (spec)
Primary analysis (n = 10,587, 90 studies)		96.6 (95.2, 97.7) [64.4, 99.8]	98.9 (98.1, 99.4) [75.8, 100.0)	1.4	1.7
Breakdown by trimester (n = 4,467, 35 studies)	First trimester (n = 2,244, 26 studies)	95.0 (92.2, 97.3) [71.7, 99.4]	98.8 (97.0, 99.7) [64.0, 100.0)	1.0	1.7
	Second trimester (n = 1,662, 15 studies)	98.2 (95.2, 99.6) [64.9, 100.0]	99.5 (98.2, 100.0) [77.0,100]	1.6	1.6
	Third trimester (n = 561, 9 studies)	96.6 (86.6, 99.7) [28.0, 100.0]	99.0 (95.4, 99.9) [70.6, 100.0]	1.8	1.3

CI = credible interval.

PI = prediction interval.

SD = standard deviation.