Table 3. Spearman correlation coefficients of selected marker scores with cumulative exposure to radon and arsenic in lung tissue from 146 uranium miners.
| Exposure | NOTCH1 (cytoplasm) | HIF1A (cytoplasm) | MUC1 (membrane) | NKX2-1 (nucleus) | |||||
| rS | 95% CI | rS | 95% CI | rS | 95% CI | rS | 95% CI | ||
| All (N = 146) | Radon | 0.18 | (0.02;0.33) | 0.12 | (−0.04;0.28) | 0.03 | (−0.13;0.19) | 0.07 | (−0.10;0.23) |
| Arsenic | 0.23 | (0.07;0.38) | 0.03 | (−0.13;0.19) | 0.00 | (−0.16;0.16) | 0.01 | (−0.15;0.17) | |
| Lung cancer (N = 107) | Radon | 0.26 | (0.07;0.42) | 0.12 | (−0.07;0.30) | 0.07 | (−0.12;0.26) | 0.11 | (−0.08;0.29) |
| Arsenic | 0.34 | (0.16;0.49) | 0.02 | (−0.17;0.21) | 0.06 | (−0.14;0.24) | 0.00 | (−0.19;0.19) | |
| Adenocarcinoma (N = 35) | Radon | 0.31 | (−0.03;0.58) | 0.13 | (−0.21;0.44) | 0.16 | (−0.18;0.47) | −0.07 | (−0.39;0.27) |
| Arsenic | 0.73 | (0.51;0.85) | 0.05 | (−0.29;0.37) | 0.11 | (−0.23;0.43) | −0.04 | (−0.36;0.30) | |
| Squamous cell carcinoma (N = 33) | Radon | 0.34 | (−0.01;0.61) | −0.06 | (−0.40;0.29) | 0.10 | (−0.26;0.42) | – | |
| Arsenic | 0.25 | (−0.11;0.54) | −0.05 | (−0.39;0.30) | −0.03 | (−0.37;0.32) | – | ||
| Small cell lung cancer (N = 39) | Radon | 0.22 | (−0.10;0.50) | 0.21 | (−0.11;0.49) | −0.20 | (−0.48;0.13) | 0.46 | (0.16;0.67) |
| Arsenic | 0.28 | (−0.05;0.54) | 0.00 | (−0.31;0.32) | 0.16 | (−0.16;0.45) | 0.14 | (−0.19;0.43) | |
| Cancer-free samples (N = 39) | Radon | −0.12 | (−0.42;0.20) | 0.10 | (−0.22;0.40) | 0.12 | (−0.20;0.42) | 0.17 | (−0.16;0.46) |
| Arsenic | −0.12 | (−0.42;0.20) | 0.03 | (−0.29;0.34) | −0.32 | (−0.57;0.00) | 0.17 | (−0.16;0.46) | |