Table 4. Proportion of lung tissue samples with positive staining of candidate proteins in lung cancer tissue and in cancer-free samples from uranium miners.

	Adenocarcinoma (N = 35)			Squamous cell carcinoma (N = 33)			Small cell lung cancer (N = 39)			Cancer-free (N = 39)
	Membrane	Cytoplasm	Nucleus	Membrane	Cytoplasm	Nucleus	Membrane	Cytoplasm	Nucleus	Membrane	Cytoplasm	Nucleus
CCND1	0	33 (94%)	28 (80%)	4 (12%)	33 (100%)	27 (82%)	0	31 (79%)	1 (3%)	0	2 (5%)	0
CD44	15 (43%)	17 (49%)	0	29 (88%)	28 (85%)	0	2 (5%)	4 (10%)	0	0	0	0
CDH1	32 (91%)	28 (80%)	0	33 (100%)	33 (100%)	0	15 (38%)	21 (54%)	0	0	0	0
CTNNB1	31 (89%)	29 (83%)	1 (3%)	32 (97%)	30 (91%)	0	6 (15%)	19 (49%)	0	0	18 (46%)	0
EGFR	27 (77%)	31 (89%)	0	33 (100%)	33 (100%)	0	7 (18%)	14 (36%)	0	0	0	0
ERBB2	1 (3%)	23 (66%)	0	0	25 (76%)	0	0	10 (26%)	0	0	0	0
HIF1A	0	35 (100%)	0	0	33 (100%)	0	0	22 (56%)	0	0	35 (90%)	3 (8%)
KIT	3 (9%)	24 (69%)	0	0	23 (70%)	0	0	21 (54%)	0	0	0	0
KRT5	5 (14%)	9 (26%)	0	32 (97%)	33 (100%)	0	1 (3%)	1 (3%)	0	0	0	0
KRT14	1 (3%)	8 (23%)	0	22 (67%)	23 (70%)	0	1 (3%)	3 (8%)	0	0	0	0
MMP2	0	27 (77%)	0	0	24 (73%)	0	0	2 (5%)	0	0	16 (41%)	0
MUC1	29 (83%)	34 (97%)	0	32 (97%)	33 (100%)	0	4 (10%)	37 (95%)	0	39 (100%)	39 (100%)	0
NKX2-1	0	0	35 (100%)	0	0	0	0	0	29 (74%)	0	0	39 (100%)
NOTCH1	0	29 (83%)	1 (3%)	0	31 (94%)	3 (9%)	0	10 (26%)	0	0	4 (10%)	0
PAK1	0	7 (20%)	23 (66%)	0	2 (6%)	22 (67%)	0	1 (3%)	17 (44%)	0	0	0
PTGS2	1 (3%)	31 (89%)	0	0	30 (91%)	1 (3%)	0	10 (26%)	0	0	0	0
SFTPC	0	33 (94%)	1 (3%)	0	33 (100%)	0	0	7 (18%)	0	0	38 (97%)	0
SNAI1	0	8 (23%)	35 (100%)	0	9 (27%)	30 (91%)	0	3 (8%)	28 (72%)	0	0	2 (5%)
STAT3	0	29 (83%)	6 (17%)	0	32 (97%)	14 (42%)	0	25 (64%)	3 (8%)	0	39 (100%)	10 (26%)
TP53	0	9 (26%)	34 (97%)	0	6 (18%)	32 (97%)	0	5 (13%)	34 (87%)	0	0	27 (69%)
VEGFA	0	34 (97%)	2 (6%)	0	33 (100%)	3 (9%)	0	29 (74%)	2 (5%)	2 (5%)	6 (15%)	0
VIM	6 (17%)	12 (34%)	0	8 (24%)	11 (33%)	0	0	5 (13%)	0	0	3 (8%)	0