Table 1. PK Parameters following IV Administration of a Single Dose of 10 mg/kg of Anti-oxLDL (Assay A).
Animal ID (Sex) | AUCinf(day•µg/mL) | CL(mL/day/kg) | T1/2α(day) | T1/2β(day) | Cmax(µg/mL) | V1(mL/kg) | Vss(mL/kg) |
1 (F) | 681 | 14.7 | 1.13 | 8.37 | 177 | 56.6 | 126 |
2 (M) | 642 | 15.3 | 0.565 | 8.75 | 153 | 64.0 | 168 |
3 (F) | 1102 | 9.44 | 1.30 | 11.8 | 229 | 45.5 | 116 |
4 (M) | 591 | 17.4 | 0.324 | 8.68 | 163 | 63.1 | 198 |
Mean | 754 | 14.2 | 0.831 | 9.40 | 180 | 57.3 | 152 |
SD | 235 | 3.39 | 0.462 | 1.60 | 33.5 | 8.52 | 38.2 |
SD: standard deviation.