Table 2. blood concentration of the 29 biomarkers between stroke (N = 103) and control patients (N = 132) in cohort 1.
| Molecules | Controls | Stroke | p value* |
| Mean± SD | Mean± SD | ||
| Median (Min.- Max.) | Median (Min.- Max.) | ||
| GST-π | 17.3±9.8 | 41.6±51.3 | <.001 |
| 15.2 (6.1–60.6) | 20.1 (4.8–320.1) | ||
| DJ1 | 74.9±140.1 | 161.7±355.7 | <.001 |
| 39.7 (0–1399.0) | 69.9 (2.8–3036.8) | ||
| NDKA | 5.5±5.8 | 15.8±36.7 | <.001 |
| 3.9 (0.5–47.0) | 5.8 (0.0–276.6) | ||
| NT-proBNP | 316.0±639.9 | 1244.9±2180.2 | <.001 |
| 115.5 (20.0–5180.0) | 416.0 (20.0–10776.0) | ||
| IL-6 | 31.1±209.9 | 97.0±497.0 | <.001 |
| 4.3 (0.0–2108.6) | 7.0 (0.0–4366.9) | ||
| MMP-3 | 17.7±15.5 | 14.0±14.6 | .008 |
| 13.4 (1.7–104.0) | 10.7 (0.0–12.2) | ||
| UFD-1 | 7.3±20.4 | 7.7±17.1 | 0.01 |
| 2.1 (0.0–147.0) | 2.8(0.0–143.0) | ||
| IL-1ra | 76.1±234.2 | 312.5±1321.4 | .012 |
| 15.2 (0.0–1758.4) | 34.0 (0.0–9411.7) | ||
| IL-8 | 6.4±69.0 | 65.4±366.7 | .015 |
| 0.0 (0.0–786.3) | 0.0 (0.0–3349.9) | ||
| S100β | 12.5±34.4 | 40.3±87.9 | .015 |
| 0.0 (0.0–339.4) | 4.65 (0.0–505.6) | ||
| CRP | 7.2±35.7 | 8.1±14.7 | .017 |
| 1.8 (0.0–400.0) | 3.12 (0.0–107.7) | ||
| Troponin I | 40.3±24.7 | 102.6±674.4 | .017 |
| 20.0 (0.0–2790) | 20.0 (0.0–685.0) | ||
| H-FABP | 2.1±2.1 | 4.1±8.0 | .024 |
| 1.5 (0.2–15.7) | 1.8 (0.07–74.1) | ||
| E-selectin | 42.5±30.9 | 34.5±16.2 | .046 |
| 35.7 (11.7–233.5) | 32.5 (10.9–98.2) | ||
| VEGF | 127.8±812.1 | 131.3±282.0 | 0.15 |
| 15.7 (0.0–9261.5) | 32.1 (0.0–2177.8) | ||
| G-CSF | 28.2±128.6 | 35.6±106.6 | 0.17 |
| 12.6 (0.0–1470.2) | 15.9 (0.0–996.8) | ||
| IL-9 | 50.6±326.3 | 74.8±262.3 | 0.18 |
| 1.0 (0.0–3670.8) | 1.7 (0.0–1575.1) | ||
| IL-10 | 72.1±311.7 | 77.8±199.3 | 0.22 |
| 38.6 (0.0–3571.9) | 42.9 (0.0–1833.1) | ||
| IFN-γ | 17.9±79.0 | 59.3±269.6 | 0.22 |
| 4.0 (0.0–715.0) | 5.6 (0.0–2464.8) | ||
| VCAM | 620.2±200.4 | 663.9±241.1 | 0.29 |
| 589.8 (95.5–1321.5) | 615.0 (283.7–1409.0) | ||
| IL-1b | 2.6±13.5 | 24.9±206.7 | 0.35 |
| 0.8 (0.0–125.1) | 0.8 (0.0–2087.6) | ||
| P-Selectin | 119.0±52.6 | 151.0±131.9 | 0.37 |
| 117.7 (37.4–364.0) | 115.7 (35.4–812.1) | ||
| MMP-1 | 5.0±5.7 | 4.2±4.0 | 0.37 |
| 3.5 (0.3–47.0) | 3.5 (0.1–26.6) | ||
| IP-10 | 784.1±908.3 | 732.6±779.5 | 0.65 |
| 510.4 (15.5–8016.1) | 500.3 (0.0–4747.1) | ||
| MIP-1b | 132.1±112.1 | 143.3±206.8 | 0.67 |
| 109.8 (5.0–1032.9) | 110.7 (3.7–2005.4) | ||
| ICAM | 270.1±139.9 | 254.1±101.1 | 0.68 |
| 257.7 (47.2–1117.5) | 250.4 (83.4–566.7) | ||
| TNF-α | 24.2±147.9 | 72.0±349.7 | 0.72 |
| 6.1 (0.0–1598.0) | 6.4 (0.0–2925.5) | ||
| MIP-1a | 65.7±747.3 | 10.6±86.5 | 0.76 |
| 0.0 (0.0–8521.2) | 0.0 (0.0–873.4) | ||
| MCP-1α | 84.8±80.4 | 104.2±241.0 | 0.91 |
| 63.6 (5.3–514.6) | 62.6 (7.8–2397.7) |
*
Significant concentration was set at 0.002 after Bonferroni correction (Mann-Whitney U tests, two-tailed tests).