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. 2012 Sep 17;7(9):e44871. doi: 10.1371/journal.pone.0044871

Figure 6. Knock-down of Nubp1 causes centrosome multiplication and alteration in centrsome dynamics.

Figure 6

(A–B) A549 cells stably transfected with GFP-Centrin were either transfected with control or Nubp1 specific siRNA. Represented is a time sequence showing the movement of the centriole pair in control cells and the aberrant numbers, increased and irregular centrosome movements in Nubp1 knock-down cells. (C–F) Knock-down of Nubp1 leads to multiple microtubule organization points and decreased acetylated-tubulin. A549 cells were transfected with either control or Nubp1 siRNA and stained for the indicated antigens.