Table 3.
TDT and pseudosibling based case-control analysis of activating FcγR gene variants among IVIG responding and IVIG non-responding Kawasaki patients in three racial/ethnic groups†
| Genes & Polymorphisms | IVIG Responders
|
IVIG non-responders
|
||||||
|---|---|---|---|---|---|---|---|---|
| TDT statistics
|
Pseudosibling case-control†
|
TDT statistics
|
Pseudosibling case-control†
|
|||||
| Informative families* | z-statistics (p-value) | OR (95% CI) | p | Informative families* | z-statistics (p-value) | OR (95% CI) | p | |
| FcγRIIA-131H/R | ||||||||
| All | 115 | +2.1 (0.04) | 1.40 (1.01–1.95) | 0.04 | 41 | +1.81 (0.07) | 1.72 (0.96–3.08) | 0.07 |
| Caucasians | 67 | +0.97 (0.33) | 1.24 (0.81–1.90) | 0.33 | 21 | +0.76 (0.45) | 1.33 (0.63–2.82) | 0.45 |
| Asians | 17 | +2.40 (0.02) | 4.00 (1.34–11.96) | 0.01 | - | - | 4.00 (0.45–35.79) | 0.21 |
|
| ||||||||
| FcγRIIIA-158V/F | ||||||||
| All | 108 | −0.25 (0.80) | 1.00 (0.72–1.39) | 1 | 40 | +1.48 (0.14) | 1.5 (0.83–2.72) | 0.18 |
| Caucasians | 67 | +0.43 (0.67) | 1.10 (0.72–1.68) | 0.67 | 22 | +0.82 (0.41) | 1.4 (0.62–3.15) | 0.42 |
| Asians | 19 | −2.04 (0.04) | 4.00 (1.34–11.96) | 0.01 | - | - | - | - |
|
| ||||||||
| FcγRIIIB-NA1 | ||||||||
| All | 95 | +1.51 (0.13) | 1.28 (0.89–1.82) | 0.18 | 34 | +3.70 (0.0002) | 3.67 (1.75–7.66) | 0.0006 |
| Caucasians | 48 | +1.21 (0.23) | 1.29 (0.79–2.10) | 0.32 | 20 | +2.71 (0.007) | 3.6 (1.34–9.70) | 0.01 |
| Asians | 22 | +0.82 (0.41) | 2.14 (0.87–5.26) | 0.10 | - | - | - | - |
*
TDT statistics was only performed where there were 10 or more informative families;
†
OR (additive) based on the genotype of the KD patients and pseudosibling controls derived from the 3 alternate genotypes based on the untransmitted alleles