Table 4.
Results of TDT and pseudosibling based case-control analysis of polymorphisms in activating FcγR genes among Kawasaki disease patients with and without coronary artery disease (CAD) in three racial/ethnic groups†
| Genes & Polymorphisms | KD patients without CAD (n = 331)
|
KD patients with CAD (n = 86)
|
||||||
|---|---|---|---|---|---|---|---|---|
| TDT statistics
|
Pseudosibling case-control†
|
TDT statistics
|
Pseudosibling case-control†
|
|||||
| Informative families* | z-statistics (p-value) | OR (95% CI) | p | Informative families* | z-statistics (p-value) | OR (95% CI) | p | |
| FcγRIIA-131H/R | ||||||||
| All | 127 | +1.79 (0.07) | 1.33 (1.02–1.82) | 0.07 | 43 | +2.45 (0.01) | 1.89 (1.10–3.33) | 0.03 |
| Caucasians | 79 | +2.05 (0.04) | 1.52 (1.01–2.22) | 0.04 | 20 | 0 (1) | 1.00 (0.46–2.16) | 1 |
| Asians | 17 | +1.15 (0.25) | 0.58 (0.23–1.48) | 0.26 | - | - | - | - |
|
| ||||||||
| FcγRIIIA-158V/F | ||||||||
| All | 134 | −0.23 (0.82) | 0.96 (0.71–1.31) | 0.81 | 40 | +1.66 (0.10) | 1.57 (0.88–2.80) | 0.13 |
| Caucasians | 91 | 0 (1) | 1.00 (0.69–1.55) | 1 | 18 | +0.85 (0.39) | 1.44 (0.62–3.38) | 0.40 |
| Asians | 21 | −1.63 (0.10) | 0.50 (0.21–1.17) | 0.11 | - | - | - | - |
|
| ||||||||
| FcγRIIIB-NA1 | ||||||||
| All | 113 | +0.65 (0.52) | 1.09 (0.80–1.49) | 0.58 | 35 | +2.41 (0.02) | 2.13 (1.11–4.00) | 0.02 |
| Caucasians | 63 | +1.07 (0.29) | 1.24 (0.81–1.85) | 0.28 | 17 | +1.34 (0.18) | 1.85 (0.70–4.76) | 0.19 |
| Asians | 21 | +0.82 (0.41) | 1.41 (0.62–3.15) | 0.42 | - | - | - | - |
*
TDT statistics was only performed where there were 10 or more informative families (several SNPs, specifically FcγRIIIA-48R/L did not have enough informative families especially in Asians and Hispanics);
†
OR (additive) based on the genotype of the KD patients and pseudosibling controls derived from the 3 alternate genotypes based on the untransmitted alleles