Table 2.

Pre-dose and post-dose whole brain mean baseline CBF values

Subject	Eyes-closed				Eyes-open
	Caffeine Session CBF ml/(100 g min)		Control Session CBF ml/(100 g min)		Caffeine Session CBF ml/(100 g min)		Control Session CBF ml/(100 g min)
	Pre	Post	Pre	Post	Pre	Post	Pre	Post
1	72.2	56.4	78.4	66.6	67.9	51.6	69.0	65.3 1
2	57.7	42.6	60.5	62.0	57.4	39.9	61.9	66.6
3	58.8	47.4	55.1	59.8	57.2	46.2	61.4	63.3
4	72.7	59.5	72.0	71.7	72.7	58.5	72.9	69.0
5	63.3	56.6	68.0	65.8	64.5	56.9	70.6	68.7
6	70.4	45.8	69.8	71.3	69.9	49.5	69.9	66.5
7	66.8	42.4	66.2	64.9	60.9	40.1	59.1	61.7
8	59.6	44.3	59.0	54.5	55.3	42.8	58.1	52.9
9	78.9	61.4	64.1	61.2	72.3	56.9	62.8	58.3
10	74.6	59.7	73.2	74.7	74.1	61.0	82.7	76.8
Mean	67.5	51.6	66.6	65.2	65.2	50.3	66.8	64.9
SD	7.4	7.8	7.1	6.2	7.1	7.9	7.6	6.5
p-value	6e-6		0.35		1e-6		0.13

Mean values were computed across voxels with grey matter partial volume >0.8. Significance values were computed with two-tailed paired t tests.