Table 2.
Traffic and related receptor gene expression that are important for skin and lung inflammation: There is a lack of Th2 related receptor gene expression. Cxcr3 and Cxcr6 expression are not dependent on IL2. Cxcr3 is induced by interferon γ and the expression of Cxcr6 is enhanced by both Th1 and Th2 cytokines. The expression of the adhesion molecule Integrin, alpha E (ITGAE, CD103) is controlled by IL-2.
| Receptor gene | B6 | Sf | Sf.II2−/− | Sf.ll4−/− or Sf. Stat6−/− | Sf.lfng−/− | |
|---|---|---|---|---|---|---|
| Th2-related | Cysltr1* | −** | +++ | − | + | +++ |
| Ltb4r1 | − | +++ | − | + | +++ | |
| II1rl1 | − | +++ | − | + | +++ | |
| Ptgir | − | ++ | − | + | +++ | |
| Th1-related | Cxcr3 | − | +++ | +++ | +++++ | − |
| Th1- and Th2-related | Ccr1 | − | ++ | − | ++ | ++ |
| Ccr8 | − | + | − | + | + | |
| Cxcr6 | − | + | + | ++++ | ++ | |
| Adhesion | Itgae | − | +++ | − | +++ | +++ |
*
Cysltr1, cysteinyl leukotriene receptor 1; Ltb4r1, leukotriene B4 receptor 1; Ptgir, prostaglandin I2 (prostacyclin) receptor (IP); Itgae, integrin αE.
**
(−) designates the baseline level in B6 mice.