TABLE 2.
ECMO | Non-ECMO | P | |
---|---|---|---|
V (L/kg) | 1.5 (1.3, 1.7) | 1.0 (0.8, 1.4) | 0.02 |
CL (ml/h/kg) | 17 (14, 22) | 18 (14, 22) | 0.57 |
t1/2 (h) | 60 (47, 76) | 39 (24, 79) | 0.49 |
AUC0–24 (h*mg/L) | 322 (307, 343) | 476 (366, 492) | 0.01 |
Data for historical controls were extracted from Piper et al. minus their infant on ECMO and compared using Wilcoxon signed-rank test.
ECMO indicates extracorporeal membrane oxygenation; V, volume of distribution; CL, clearance; t1/2, half-life; AUC0–24,area under the curve from 0–24 hours. All values are median (interquartile range).