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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Pediatr Infect Dis J. 2012 Oct;31(10):1042–1047. doi: 10.1097/INF.0b013e31825d3091

TABLE 2.

Pharmacokinetic Indices in Infants on ECMO after the First Dose of Intravenous Fluconazole 25 mg/kg Compared with Historical Controls not on ECMO who Received 1 Dose of Intravenous Fluconazole 25 mg/kg12

ECMO Non-ECMO P
V (L/kg) 1.5 (1.3, 1.7) 1.0 (0.8, 1.4) 0.02
CL (ml/h/kg) 17 (14, 22) 18 (14, 22) 0.57
t1/2 (h) 60 (47, 76) 39 (24, 79) 0.49
AUC0–24 (h*mg/L) 322 (307, 343) 476 (366, 492) 0.01

Data for historical controls were extracted from Piper et al. minus their infant on ECMO and compared using Wilcoxon signed-rank test.

ECMO indicates extracorporeal membrane oxygenation; V, volume of distribution; CL, clearance; t1/2, half-life; AUC0–24,area under the curve from 0–24 hours. All values are median (interquartile range).